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What is the mechanism of action of sildenafil oral jelly 100mg kamagra?

The mechanism of action of Sildenafil Oral Jelly 100mg, including the Kamagra brand, is based on the active ingredient sildenafil citrate. Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor, and its primary role is to enhance the effects of nitric oxide (NO) in the body. Here is a step-by-step explanation of how it works:

Initiation of Sexual Stimulation:

Sexual arousal triggers the release of nitric oxide (NO) in the erectile tissue of the penis.
NO-Mediated Activation:

Nitric oxide activates an enzyme called guanylate cyclase.
cGMP Production:

Guanylate cyclase converts guanosine triphosphate (GTP) into cyclic guanosine monophosphate (cGMP).
Relaxation of Smooth Muscle:

Increased levels of cGMP cause the smooth muscles of the penile arteries to relax.
Dilation of Blood Vessels:

The relaxation of smooth muscles allows an increased flow of blood into the penis, leading to an erection.
PDE5 Inhibition by Sildenafil:

Phosphodiesterase type 5 (PDE5) is an enzyme that breaks down cGMP, limiting its duration of action.
Sildenafil inhibits PDE5, preventing the breakdown of cGMP and allowing it to accumulate.
Prolonged Vasodilation:

With PDE5 inhibited, cGMP levels remain elevated, leading to prolonged vasodilation and sustained blood flow in the penile tissues.
Maintenance of Erection:

The sustained blood flow helps maintain the erection throughout sexual activity.
It's important to note that Sildenafil Oral Jelly, like other formulations of sildenafil, is designed to treat erectile dysfunction by facilitating the physiological processes involved in achieving and maintaining an erection. It should be used under the guidance of a healthcare professional, and individuals should follow prescribed dosage instructions and safety guidelines.